This year, Kinetic River proudly marks 15 years since its founding!

What began in Dr. Vacca’s home office in 2010—driven by a vision to transform flow cytometry with cutting-edge technology—has grown into a thriving company with a dedicated team, a 2,500 sq. ft. lab and office space in Mountain View, California, and instruments installed in prestigious institutions around the world.

Along the way, we’ve delivered custom analyzers like the Danube and the Potomac, and have been awarded over $8M in NIH SBIR funding for pioneering work in time-resolved and label-free flow cytometry.

Over the past 15 years, we’ve built a robust IP portfolio—now spanning 27 patents in four separate families, five trademarks, and international coverage—and expanded our global footprint through strategic partnerships, even amid the challenges of the pandemic. From virtual conferences and new service offerings to the launch of the Delaware Flow NanoCytometer® with 6-nm resolution, we’ve remained committed to pushing boundaries in biomedical innovation.

We are deeply grateful to our team, clients, collaborators, and supporters—past and present—who have helped shape our journey. Reaching 15 years, in an industry where most startups don’t survive past six, is no small feat. Thank you for being part of it.

Here’s to the future of Kinetic River—Where Light Meets Life.

In June, Kinetic River completed the delivery and installation of our flagship product, the Delaware Flow NanoCytometer, for the Academia Sinica’s Institute of Atomic and Molecular Sciences in Taipei, Taiwan.

This Delaware was tailored to Professor and Lab Director Ching-Wei Lin’s specifications and is being used to test infrared-fluorescence nanoparticle biomarkers. With this build, we continued to push the limits of the Delaware’s performance, and we were able to achieve new milestones in quantitative fluidic control and measurement.

Our founder and CEO, Dr. Giacomo Vacca, and principal scientist Ann Lu spent several days working with Dr. Lin and his team in his laboratory on the National Taiwan University campus, overseeing the placement, set-up, and installation verification of the instrument.

Once the instrument was hooked up, we ran initial tests on stained live cells and immediately got very strong signals. The Academia Sinica team had previously run the same tests on a Beckman Coulter CytoFLEX, and was eager to see how the Delaware performance would compare. The graph above shows that the positive population of interest, in the purple circle, had signals 100x stronger than on the CytoFLEX.

This deployment could not have gone better! Thank you to the Academia Sinica, Professor Lin, and his team for supporting us in this endeavor. With their help, we achieved a smooth and successful installation, and obtained immediate, strong results from a novel customized analyzer.

Within the same month as the Taiwan installation above, Kinetic River completed a second international Delaware deployment for the state-of-the-art Center for Advanced Studies and Technology (CAST) at the University “G. d’Annunzio” of Chieti-Pescara in Italy, in the laboratory of Professor Paola Lanuti.

Professor Lanuti’s broad-ranging research on exosomes requires an instrument with high sensitivity, multicolor analysis, and the flexibility to run a wide variety of samples, making the Delaware an ideal fit for their work.

Our founder and CEO, Dr. Giacomo Vacca, and our principal scientist, Alan Chin, traveled to Italy to work onsite with our Senior Account Manager for Europe, Andrea Zanella, and CytoFlowService’s Giovanni Contini to lead the installation and system demonstration for Professor Lanuti’s team.

We were all excited to see striking, high-quality data emerge right off the bat, confirming the Delaware‘s potential in the group’s cutting-edge research.

This particular Delaware will serve as a demonstration site for prospective clients across Europe, offering researchers a firsthand look at its capabilities in nanoparticle and extracellular vesicle analysis.

Thank you, U. Chieti-Pescara, Professor Lanuti, and your team, for your support and partnership. We greatly look forward to following your team’s discoveries and the valuable contributions you will make with the Delaware!

Held annually in San Francisco—just a short drive from our headquarters in Mountain View—the International Society for Optics and Photonics hosted its Photonics West conference in January.

Photonics West is not only the place to be to find out the latest and greatest in optics and lasers, but it’s also a great opportunity to create new connections with people and strengthen the ones we have.

Our founder, Giacomo Vacca, caught up with dozens of friends and colleagues, sharing ideas and stories, reminding us of how grateful we are for the community we have!

A large thanks to SPIE for hosting; we will see you again next year!

Multicolor. High Resolution. Clog-Free. Isn’t that what we all want for our analyzers?

In January, Dr. Vacca presented a webinar to the Center for Discovery and Innovation of Hackensack Meridian Health about multiparameter exosome analysis using the Delaware Flow NanoCytometer®.

Dr. Vacca highlighted the Delaware‘s best-in-class resolution of 6 nm, an unprecedented level of precision in flow cytometry.

The recorded webinar is available on our website, click the link below to learn more about what the Delaware can do!

In February, Kinetic River was proud to sponsor a workshop on Extracellular Vesicle Biomolecular Corona hosted by the International Society for Extracellular Vesicles (ISEV).

This workshop brought together experts from the synthetic and biogenic nanoparticle fields to share their research on and further explore the EV corona—a ” halo” of molecules surrounding biological nanoparticles that alter their properties.

The event was held at the University of Brescia in Italy; our Senior Account Manager for Europe, Andrea Zanella, represented Kinetic River there.

Thanks to ISEV for hosting!

The annual meeting of the International Society for Extracellular Vesicles took place in Vienna, Austria, this year, and Kinetic River was proud to present two posters on our recent work at the scientific conference.

The first poster was titled: “Paving the Way Toward A Urine-Based Extracellular-Like Vesicle Assay for Early Diagnosis of Kidney Disease”, and highlighted our work with Dr. Christopher Ward, of the University of Kansas, on developing an assay for kidney disease using our Delaware Flow NanoCytometer.

The second poster was titled: “Swarm Detection Can Be Your Friend: Rapid Estimation of Fluorescent Fraction of Stained Exosome Samples Via Flow Cytometry”, and focused on the benefits of “swarm” detection.

Thank you to Andrea Zanella, our Senior Account Manager for Europe, for representing Kinetic River at the event, and thank you to ISEV for hosting!

Click the link below to view our posters in detail.

The 38th Annual Congress of the International Society for the Advancement of Cytometry was held in Denver, Colorado this spring, and Principal Scientist Alan Chin was in attendance.

Kinetic River presented two posters on our recent research, entitled: “Paving the Way Toward a Urine-Based Extracellular Vesicle Assay for Early Diagnosis of Kidney Disease” and “Swarm Detection Can Be Your Friend: Rapid Estimation of Fluorescent Fraction of Stained Exosome Samples via Flow Cytometry”.

Click the link below if you would like to view our posters in detail and see what the Delaware can do for you!

“The Delaware‘s system allows for unparalleled multicolor analysis of EVs at excellent resolution and sensitivity, providing an enormous and essential capability for our research projects that surpasses any other platforms currently available in the market.”

Dr. Ramin Hakami, PhD
Associate Professor, School of Systems Biology
Co-Director of the Center for Infectious Disease Research (CIDR), George Mason University
Manassas, VA

“The Delaware Flow NanoCytometer is the first analyzer with the flexibility and single-exosome sensitivity needed for a urine-based assay to diagnose and stage autosomal dominant polycystic kidney disease (ADPKD).”

Dr. Christopher Ward, MBChB, PhD
Associate Professor, Nephrology and Hypertension
Jared Grantham Kidney Institute, U. of Kansas Medical Center
Kansas City, KS